![]() The current vaccines prevent COVID-19, by definition a lower respiratory tract illness, in greater than 90% of recipients ( 2– 5). But is this what happened in these cases? In most cases, the answer is no, and this answer lies in the fundamental understanding of the mucosal immune system throughout the respiratory tract: the upper respiratory tract and the lower respiratory tract. Moreover, the use of the term “breakthrough” infections implies that the virus broke through a protective barrier provided by the vaccine. These reports have the potential to undermine public confidence in the efficacy of these vaccines. ![]() Recently, there have been several reports of SARS-CoV-2 “breakthrough” infections that have occurred in recipients of the FDA-approved SARS-CoV-2 vaccines ( 1).
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